Divisional meeting of the Russian Academy of Medical Sciences
Transfer Factor is a Modifier of Biological Age
A.G. Chizhov, V.A. Santalova- Russian People's Friendship University, Moscow
There is a close link between the decrease of functional activity of the immune system and aging. Thus, we decided to study immunomodulators to determine to what extent they may affect biological age indices. A new immune theory of aging (V.I.Dontsov, V.N. Krut'ko, 2002) points to the role of specific T-lymphocytes subpopulations in sustaining a certain level of normal cellular growth in the body and dwells on the importance of their functional decrease having a strong impact on aging. Stimulation of the function of these cells by Transfer Factor (TF), an immunomodulator produced by 4Life, USA, seemed a plausible method of "treating aging". The evaluation of the role TF in the process of aging is at the basis of this study.
Twelve (12) men aged 55-73 were included in the study. A dose of 300 mg. of the TF product was given daily with meals 5 times a week for 6 weeks. Biological age was determined using the "APK" method ("Diagnostics of aging: biological age" (National gerontology center, Moscow)). The following biomarkers were used for making the determinations: AP (arterial pressure), pulse wave velocity, VC (vital pulmonary capacity), static balance, Shtange's test, adaptation testing, body mass, left hand strength, Shulte's test, Veksler's test, neuromuscular test, hearing frequency threshold and the SAN's questionnaire. The functional activities of body systems were evaluated by means of Nakatani's electropuncture diagnostics. Chronological age of the group was 63.5 . Before the use of TF the biological age of the group differed from chronological by 4.2 years. The majority of men demonstrated a decrease in the functional activity of endocrine and of immune systems' as well as hyperfunction of the liver and of urinary bladder and hypofunction pancreatic.
Results: The study showed that initially disturbed body system functions were significantly normalized. After the course of TF treatment the difference between biological and chronological age was 8.2 years,